The FDA recently approved neffy, a groundbreaking nasal spray manufactured by ARS Pharma. This innovative product is the first of its kind, offering a new approach to treating severe allergic reactions.
What is epinephrine?
Epinephrine, also known as adrenaline, is a crucial medication for treating severe allergic reactions, known as anaphylaxis. During an allergic reaction, the body releases chemicals that can cause the airways to tighten and blood pressure to drop, posing a life-threatening risk. Epinephrine works rapidly to reverse these symptoms by opening the airways and raising blood pressure, making it easier to breathe and preventing shock.
What is neffy?
neffy is a new nasal spray approved for treating severe allergic reactions, or anaphylaxis. It delivers epinephrine through a single dose sprayed into one nostril. Studies have shown that neffy provides similar levels of epinephrine in the blood as traditional epinephrine injections and works effectively to raise blood pressure and heart rate, which are crucial for managing anaphylaxis. For children over 66 pounds, neffy’s effects are comparable to those in adults. If symptoms don’t improve, a second dose can be used. However, patients should still seek emergency medical help for further treatment and monitoring.
What are the common side effects of neffy?
The most common side effects of neffy include:
Additional warnings include:
May not be suitable for those with certain nasal conditions or a history of nasal surgery.
Consult a healthcare professional if you have specific coexisting conditions or sulfite allergies.
Differences between nasal spray epinephrine and autoinjector epinephrine
Traditionally administered as an injection (such as with an EpiPen), epinephrine can now also be delivered as a nasal spray, providing a quick and effective option for emergency treatment.
neffy | EpiPen | |
Administration | Nasal spray administered in one nostril | Delivered via injection administered typically into outer thigh |
Usage | Needle-free option | Requires quick injection |
Dosage | Single dose (2mg) but can be followed by a second spray in the same nostril if needed | Contains a pre-measured dose (0.3mg Epipen and 0.15mg EpiPen Junior) for single use |
Onset of Action | Rapid delivery | Rapid delivery |
Suitability | Ideal for those who prefer a needle-free option, though it may not be suitable for individuals with certain nasal conditions | May be preferred for patients who are comfortable with injections or have specific conditions affecting nasal absorption |
Size | Compact and slim, making it easier to carry in a pocket or small bag | Large and bulky, designed to be carried in a protective case |
Out-of-Pocket Cost | 〜$200 for 2 doses | 〜$600 for 2 EpiPens (〜$150-$350 for generic versions) |
Is neffy animal-free?
VeganMed is thrilled to confirm that neffy is animal-free! The nasal spray contains no ingredients derived from animals, and the device itself is also free from animal-based components. This makes neffy a suitable choice for those who prefer products without animal derivatives. Plus, we're happy to share that neffy is also carrageenan-free!
Why a Needle-Free Epinephrine Option is Important
neffy marks a significant advancement in treating severe allergic reactions, providing a needle-free alternative to traditional epinephrine auto-injectors. With 25 to 40 million people in the U.S. at risk for anaphylaxis, and many avoiding epinephrine injections due to needle discomfort, neffy offers a crucial solution. Its ease of use can help ensure timely treatment, especially for individuals with conditions like Alpha-gal Syndrome who carry auto-injectors. By making life-saving treatment more accessible and less intimidating, neffy has the potential to improve outcomes and reduce the need for emergency services or hospitalization.
Co-author: Shaan Ashraf, PharmD
Disclaimer: The product and/or information provided on VeganMed is of a general nature and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. We do not lab test the products to confirm that they are free from animal ingredients, and it is possible that the formulation and ingredients could have changed. Always seek the advice of your physician or other qualified healthcare provider with any questions you may have regarding a medical condition or product. The information provided in this post is accurate and up to date as of the date it was written. However, please note that circumstances and facts may change over time, and new information may become available that could alter the accuracy or relevance of the content. We encourage readers to verify and cross-reference any information provided here with trusted sources or consult relevant professionals for the most current and accurate updates.
Looking for certified and verified animal-free products?
Thank you for your awareness and concern for animal-derived ingredients!
As a reminder, please comment on our FDA Citizen Petition, requesting clear labeling of animal-derived ingredients in medications. Together, we can make a difference.
If you have any further questions about ingredients in your medicines and supplements, feel free to reach out to the VeganMed team!
Comentarios